FEN1 UPREGULATION MEDIATED BY SUMO2 VIA ANTAGONIZING PROTEASOMAL DEGRADATION PROMOTES HEPATOCELLULAR CARCINOMA STEMNESS

FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness

Purpose: Metastasis of hepatocellular carcinoma (HCC) critically impacts the survival prognosis of patients, with the pivotal role of hepatocellular carcinoma stem cells in initiating invasive metastatic behaviors.The Flap Endonuclease 1 (FEN1) is delineated as a metallonuclease, quintessential for myriad cellular processes including DNA replicatio

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Digital Gaming and Exercise Among Youth With Type 1 Diabetes: Cross-Sectional Analysis of Data From the Type 1 Diabetes Exercise Initiative Pediatric Study

Abstract BackgroundRegular physical activity and exercise are fundamental components of a healthy lifestyle for youth living with type 1 diabetes (T1D).Yet, few youth living with T1D achieve the daily minimum recommended levels of physical activity.For all youth, regardless of their disease status, minutes of physical activity compete with other da

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